Metoclopramide and Tetracycline Interaction
Drug interaction information between Metoclopramide and Tetracycline.
Metoclopramide and Tetracycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoclopramide and Tetracycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide makes the stomach empty faster, which can cause the body to absorb more of the tetracycline antibiotic than usual.
FDA Label Information
digoxin) by metoclopramide, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Metoclopramide + Tetracycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Tetracycline's 12. In the minor band specifically: Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Atovaquone/Proguanil, Atropine); Tetracycline has 8 (also Zinc Sulfate, Atovaquone/Proguanil, Cholestyramine, Colestipol).
What mechanism field is on file for Metoclopramide and Tetracycline?
Metoclopramide makes the stomach empty faster, which can cause the body to absorb more of the tetracycline antibiotic than usual.
Metoclopramide's labeled portfolio outnumbers Tetracycline
SPL source-record counts only. This page's band is minor · classes on file: Metoclopramide (Prokinetic / Antiemetic); Tetracycline (Tetracycline Antibiotic).
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Atovaquone/Proguanil
- Atropine
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Zinc Sulfate
- Atovaquone/Proguanil
- Cholestyramine
- Colestipol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.