Carbidopa/Levodopa · larger labeled portfolio than Methyldopa
SPL labels Carbidopa/Levodopa + Methyldopa as moderate; Carbidopa/Levodopa 8 / Methyldopa 3 in that band.
Mechanism on file: Both of these drugs are processed by the same enzyme in the body. Taking them together can cause the drugs to build up, which may lead to a fast heart rate or changes in blood pressure.
FDA SPL severity: Moderate
Carbidopa/Levodopa + Methyldopa · SPL mechanism field
Both of these drugs are processed by the same enzyme in the body. Taking them together can cause the drugs to build up, which may lead to a fast heart rate or changes in blood pressure.
Moderate band excerpt · Carbidopa/Levodopa with Methyldopa
7.2 Drugs Metabolized by Catechol-O-Methyltransferase (COMT) Drugs known to be metabolized by COMT, such as isoproterenol, epinephrine, norepinephrine, dopamine, dobutamine, alpha-methyldopa, apomorphine, isoetherine, and bitolterol should be administered with caution in patients receiving entacapone regardless of the route of administration (including inhalation), as their interaction may result in increased heart rates, possibly arrhythmias, and excessive changes in blood pressure [ see Warnings and Precautions (5.10) ].
Carbidopa/Levodopa · 13 SPL pairs (broader portfolio than Methyldopa)
- Dobutamine moderate
- Dopamine moderate
- Entacapone moderate
- Epinephrine moderate
Methyldopa · 3 moderate + 7 total pairs
- Ferrous Sulfate moderate
- Tranylcypromine moderate
- Colestipol minor
- Enalapril minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.