Bazedoxifene and Itraconazole Interaction
Drug interaction information between Bazedoxifene and Itraconazole.
Bazedoxifene and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bazedoxifene and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzyme your body uses to break down this medicine, which leads to higher levels of the drug in your system.
FDA Label Information
Concomitant administration of itraconazole, a strong CYP3A4 inhibitor, with DUAVEE, resulted in increases in bazedoxifene exposure (40%) and, to a lesser extent, conjugated estrogens exposure (9% for baseline-adjusted total estrone, 5% for total equilin), compared to DUAVEE alone [see Pharmacokinetics (12.3) ] .
Bazedoxifene Also Interacts With
- Atorvastatin minor
- Carbamazepine minor
- Rifampin minor
- Phenytoin minor
- Phenobarbital minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Bazedoxifene/Conjugated Estrogens + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Bazedoxifene's 7. In the minor band specifically: Bazedoxifene has 7 (also Atorvastatin, Carbamazepine, Rifampin, Phenytoin); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Bazedoxifene/Conjugated Estrogens and Itraconazole?
Itraconazole blocks the enzyme your body uses to break down this medicine, which leads to higher levels of the drug in your system.
Itraconazole carries more major-labeled pairs than Bazedoxifene
SPL source-record counts only. This page's band is minor · classes on file: Bazedoxifene (SERM / Estrogen Combination); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Bazedoxifene's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Bazedoxifene
- Atorvastatin
- Carbamazepine
- Rifampin
- Phenytoin
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.