Prescription medication · SERM / Estrogen Combination

bazedoxifene/conjugated estrogens

Also sold as Duavee. Duavee is used to treat moderate to severe hot flashes caused by menopause.

Data updated 2026-05-15

7
InteractionsFew interactions
$6.29
Brand price (NADAC)

bazedoxifene/conjugated estrogens (Duavee) is a prescription SERM / Estrogen Combination. Duavee is used to treat moderate to severe hot flashes caused by menopause.

Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body. It is used to treat menopause symptoms and prevent bone loss after menopause in women with a uterus.

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Drug Pricing (NADAC)

Brand Price

$6.29/unit

Generic Available

No

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Duavee is used to treat moderate to severe hot flashes caused by menopause.

Common side effects

Muscle spasms, Nausea, Diarrhea

Key warnings

Duavee has serious warnings.

The sections below are summarized in plain English from bazedoxifene/conjugated estrogens's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Duavee contains two medicines. Estrogen helps with menopause symptoms and bone loss. Bazedoxifene blocks estrogen's effects in the uterus, which lowers the risk of uterine cancer that can happen when taking estrogen alone.

Serious Warnings

Duavee has serious warnings. It can increase the risk of uterine cancer, stroke, blood clots, and dementia. Women taking Duavee should not take additional estrogens. Estrogen should not be used to prevent heart disease or dementia. Talk to your doctor about the risks and benefits of Duavee.

Known Drug Interactions

minor atorvastatin

7.3 Atorvastatin Concomitant administration of bazedoxifene (40 mg daily) and atorvastatin (20 mg, single-dose) to healthy postmenopausal women did not affect the pharmacokinetics of bazedoxifene, atorvastatin or its active metabolites.

Mechanism: Studies show that these two medicines do not significantly change how the body processes each drug.

minor carbamazepine

John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.

Mechanism: Carbamazepine causes your body to break down estrogens and bazedoxifene faster than usual. This can lower the amount of medicine in your blood and make it less effective.

minor rifampin

John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.

Mechanism: Rifampin speeds up the removal of these medicines from your system, which can lead to lower drug levels in your body. This may cause the treatment to be less effective or lead to changes in bleeding patterns.

minor itraconazole

Concomitant administration of itraconazole, a strong CYP3A4 inhibitor, with DUAVEE, resulted in increases in bazedoxifene exposure (40%) and, to a lesser extent, conjugated estrogens exposure (9% for baseline-adjusted total estrone, 5% for total equilin), compared to DUAVEE alone [see Pharmacokinetics (12.3) ] .

Mechanism: Itraconazole blocks the enzyme your body uses to break down this medicine, which leads to higher levels of the drug in your system.

minor phenytoin

The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.

Mechanism: Phenytoin speeds up the process your body uses to clear bazedoxifene, which can make the medication less effective.

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This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I take extra estrogen while taking Duavee?
No, you should not take additional estrogens while taking Duavee.
Can Duavee prevent heart disease?
No, estrogen therapy should not be used for the prevention of cardiovascular disease.
What if I have abnormal vaginal bleeding?
Tell your doctor right away if you have any unusual vaginal bleeding. They may need to do tests to rule out cancer.
Can Duavee cause blood clots?
Yes, Duavee can increase the risk of blood clots in the legs or lungs.
Is Duavee safe for women over 75?
Duavee has not been studied in women over 75, so it is not recommended for use in this age group.
Can Duavee cause dementia?
Studies suggest that estrogen may increase the risk of dementia in women over 65.
What should I do if I think I have a blood clot?
Seek immediate medical attention if you experience symptoms of a blood clot, such as leg pain, swelling, or sudden shortness of breath.
Can I take Duavee if I have liver problems?
No, you should not take Duavee if you have liver problems.
Does Duavee interact with other medications?
Yes, some medications can interact with Duavee. Tell your doctor about all the medicines you take, including herbal products.
Can Duavee cause breast cancer?
Duavee is contraindicated in women with known, suspected, or past history of breast cancer.
What are the common side effects of bazedoxifene/conjugated estrogens?
The registry lists Muscle spasms, Nausea, Diarrhea, Upset stomach, Upper abdominal pain among the most-reported FAERS reaction terms for bazedoxifene/conjugated estrogens. These counts are not an individual symptom assessment.
Does bazedoxifene/conjugated estrogens interact with other medications?
The registry has 7 documented interaction rows for bazedoxifene/conjugated estrogens. Notable source-record pairings include atorvastatin, carbamazepine, rifampin. These rows are not a complete medication review.
What drug class is bazedoxifene/conjugated estrogens?
bazedoxifene/conjugated estrogens belongs to the SERM / Estrogen Combination drug class. It requires a prescription (Rx). Duavee is used to treat moderate to severe hot flashes caused by menopause.
What pregnancy or breastfeeding source fields are listed for bazedoxifene/conjugated estrogens?
The FDA label for bazedoxifene/conjugated estrogens contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

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What the FDA Data Shows for bazedoxifene/conjugated estrogens

The FDA label for bazedoxifene/conjugated estrogens (sold under brand names such as Duavee) classifies it as a prescription-only medication in the SERM / Estrogen Combination class. Duavee is used to treat moderate to severe hot flashes caused by menopause. Official labeling lists 8 commonly reported side effects, including Muscle spasms, Nausea, Diarrhea.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 7 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: January 13, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page