Bazedoxifene and Carbamazepine Interaction
Drug interaction information between Bazedoxifene and Carbamazepine.
Bazedoxifene and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bazedoxifene and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to break down estrogens and bazedoxifene faster than usual. This can lower the amount of medicine in your blood and make it less effective.
FDA Label Information
John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.
Bazedoxifene Also Interacts With
- Atorvastatin minor
- Rifampin minor
- Itraconazole minor
- Phenytoin minor
- Phenobarbital minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Bazedoxifene/Conjugated Estrogens + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Bazedoxifene's 7. In the minor band specifically: Bazedoxifene has 7 (also Atorvastatin, Rifampin, Itraconazole, Phenytoin); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Bazedoxifene/Conjugated Estrogens and Carbamazepine?
Carbamazepine causes your body to break down estrogens and bazedoxifene faster than usual. This can lower the amount of medicine in your blood and make it less effective.
Carbamazepine carries more major-labeled pairs than Bazedoxifene
SPL source-record counts only. This page's band is minor · classes on file: Bazedoxifene (SERM / Estrogen Combination); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Bazedoxifene's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Bazedoxifene
- Atorvastatin
- Rifampin
- Itraconazole
- Phenytoin
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.