Bazedoxifene and Phenobarbital Interaction
Drug interaction information between Bazedoxifene and Phenobarbital.
Bazedoxifene and Phenobarbital have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bazedoxifene and Phenobarbital. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenobarbital makes your body process this medication faster, which can lower the amount of medicine in your blood and cause changes in uterine bleeding.
FDA Label Information
John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.
Bazedoxifene Also Interacts With
- Atorvastatin minor
- Carbamazepine minor
- Rifampin minor
- Itraconazole minor
- Phenytoin minor
Phenobarbital Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Voriconazole major
- Canagliflozin moderate
- Cenobamate moderate
Frequently Asked Questions
What SPL severity band is on file for Bazedoxifene/Conjugated Estrogens + Phenobarbital?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenobarbital has 59 labeled pairs on file vs Bazedoxifene's 7. In the minor band specifically: Bazedoxifene has 7 (also Atorvastatin, Carbamazepine, Rifampin, Itraconazole); Phenobarbital has 43 (also Estradiol, Doxycycline, Progesterone, Griseofulvin).
What mechanism field is on file for Bazedoxifene/Conjugated Estrogens and Phenobarbital?
Phenobarbital makes your body process this medication faster, which can lower the amount of medicine in your blood and cause changes in uterine bleeding.
Phenobarbital carries more major-labeled pairs than Bazedoxifene
SPL source-record counts only. This page's band is minor · classes on file: Bazedoxifene (SERM / Estrogen Combination); Phenobarbital (Anticonvulsant (Barbiturate)).
Phenobarbital has 3 major-labeled pairs vs Bazedoxifene's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Bazedoxifene
- Atorvastatin
- Carbamazepine
- Rifampin
- Itraconazole
3 major · 13 moderate · 43 minor · 59 total
- Other minor peers for Phenobarbital
- Estradiol
- Doxycycline
- Progesterone
- Griseofulvin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.