Bazedoxifene and Rifampin Interaction
Drug interaction information between Bazedoxifene and Rifampin.
Bazedoxifene and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bazedoxifene and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the removal of these medicines from your system, which can lead to lower drug levels in your body. This may cause the treatment to be less effective or lead to changes in bleeding patterns.
FDA Label Information
John's Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile. The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.
Bazedoxifene Also Interacts With
- Atorvastatin minor
- Carbamazepine minor
- Itraconazole minor
- Phenytoin minor
- Phenobarbital minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Bazedoxifene/Conjugated Estrogens + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Bazedoxifene's 7. In the minor band specifically: Bazedoxifene has 7 (also Atorvastatin, Carbamazepine, Itraconazole, Phenytoin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Bazedoxifene/Conjugated Estrogens and Rifampin?
Rifampin speeds up the removal of these medicines from your system, which can lead to lower drug levels in your body. This may cause the treatment to be less effective or lead to changes in bleeding patterns.
Rifampin carries more major-labeled pairs than Bazedoxifene
SPL source-record counts only. This page's band is minor · classes on file: Bazedoxifene (SERM / Estrogen Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Bazedoxifene's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Bazedoxifene
- Atorvastatin
- Carbamazepine
- Itraconazole
- Phenytoin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.