bazedoxifene/conjugated estrogens vs itraconazole
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Side-by-side comparison of bazedoxifene/conjugated estrogens and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Concomitant administration of itraconazole, a strong CYP3A4 inhibitor, with DUAVEE, resulted in increases in bazedoxifene exposure (40%) and, to a lesser extent, conjugated estrogens exposure (9% for baseline-adjusted total estrone, 5% for total equilin), compared to DUAVEE alone [see Pharmacokinetics (12.3) ] .
Sporanox
Duavee is a combination medicine containing estrogen and a drug that blocks estrogen in some parts of the body. It is used to treat menopause symptoms and prevent bone loss after menopause in women with a uterus.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Duavee is used to treat moderate to severe hot flashes caused by menopause. It can also help prevent bone loss (osteoporosis) after menopause. You should only use Duavee if you are at significant risk of osteoporosis and other non-estrogen medications should be carefully considered. Use Duavee for the shortest time that works for you, based on your goals and risks.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Duavee contains two medicines. Estrogen helps with menopause symptoms and bone loss. Bazedoxifene blocks estrogen's effects in the uterus, which lowers the risk of uterine cancer that can happen when taking estrogen alone.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Muscle spasms
- • Nausea
- • Diarrhea
- • Upset stomach
- • Upper abdominal pain
- • Nausea
- • Rash
- • Headache
No adverse event reports.
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Duavee has serious warnings. It can increase the risk of uterine cancer, stroke, blood clots, and dementia. Women taking Duavee should not take additional estrogens. Estrogen should not be used to prevent heart disease or dementia. Talk to your doctor about the risks and benefits of Duavee.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Do not take Duavee if you are pregnant. It can harm your unborn baby. Duavee is not for women who can get pregnant.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This bazedoxifene/conjugated estrogens vs itraconazole Comparison
bazedoxifene/conjugated estrogens is classified in the SERM / Estrogen Combination drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, bazedoxifene/conjugated estrogens has 0 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole blocks the enzyme your body uses to break down this medicine, which leads to higher levels of the drug in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for bazedoxifene/conjugated estrogens or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.