Bazedoxifene and Phenytoin Interaction
Drug interaction information between Bazedoxifene and Phenytoin.
Bazedoxifene and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bazedoxifene and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenytoin speeds up the process your body uses to clear bazedoxifene, which can make the medication less effective.
FDA Label Information
The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.
Bazedoxifene Also Interacts With
- Atorvastatin minor
- Carbamazepine minor
- Rifampin minor
- Itraconazole minor
- Phenobarbital minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Bazedoxifene/Conjugated Estrogens + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Bazedoxifene's 7. In the minor band specifically: Bazedoxifene has 7 (also Atorvastatin, Carbamazepine, Rifampin, Itraconazole); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Bazedoxifene/Conjugated Estrogens and Phenytoin?
Phenytoin speeds up the process your body uses to clear bazedoxifene, which can make the medication less effective.
Phenytoin carries more major-labeled pairs than Bazedoxifene
SPL source-record counts only. This page's band is minor · classes on file: Bazedoxifene (SERM / Estrogen Combination); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Bazedoxifene's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Bazedoxifene
- Atorvastatin
- Carbamazepine
- Rifampin
- Itraconazole
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.