What the FDA labels say about taking them together
Bazedoxifene/estrogens conjugated and phenytoin
Bazedoxifene/estrogens conjugated's FDA label of April 28, 2026 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name bazedoxifene/estrogens conjugated. The bazedoxifene/estrogens conjugated label: “The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.”
Check it at the source: the bazedoxifene/estrogens conjugated FDA label on DailyMed (effective April 28, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the bazedoxifene/estrogens conjugated label say about phenytoin?
Bazedoxifene/estrogens conjugated label, drug interactionsThe metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin.
Source: FDA drug label (Duavee), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective April 28, 2026 (SPL set e1b75458-2e5b-46b9-92c6-fa6daba3770f), via openFDA; the full label on DailyMed
What does the phenytoin label say about bazedoxifene/estrogens conjugated?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name bazedoxifene/estrogens conjugated in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bazedoxifene/estrogens conjugated | Phenytoin | |
|---|---|---|
| Labeled for | Osteoporosis | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $6.48 per tablet 0.45-20 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once