Prescription medicine
Probenecid First approved as Benemid
Probenecid (Benemid) is a prescription medicine with an FDA approval on record since 1951. FDA's NDC Directory lists it from 6 generic labelers, and pharmacies paid $0.636 per probenecid 500 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the NDA 7898 record on Drugs@FDA; every probenecid label on DailyMed.
Highlights of the record
FDA label of January 5, 2021; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageProbenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis.
Forms and strengths
- 500 mg
Film-coated tablet; tablet.
On the market
- Earliest approval on file
- April 26, 1951 Benemid, Merck; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 6 first January 13, 1976; 3 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 6 of which 6 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.636 per tablet Probenecid 500 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 1,173 through July 30, 2026
What is probenecid used for?
From the label: indications and usageProbenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis. As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given.
Conditions named in the indications of probenecid's FDA labels, with every medicine labeled for each:
From other probenecid labelsGout: INDICATIONS AND USAGE Probenecid tablets are indicated for the treatment of the hyperuricemia associated with gout and gouty arthritis.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
Is there a generic for probenecid (Benemid)?
The FDA approved the first generic probenecid on January 13, 1976. 6 generic applications are approved; 3 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists probenecid from 6 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1951 earliest approval on file
- 1976 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for probenecid (Benemid)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.636 per Probenecid 500 mg tablet, down 12% from $0.724 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Probenecid 500 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Probenecid 500 mg tablet | Generic | $0.636 per tablet | $19.08 | -12% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the probenecid label say about other medicines?
The probenecid label names 13 other medicines in its interaction, contraindication or warning sections. The labels of 46 other medicines name probenecid. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Acetaminophen | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Colchicine | warnings | WARNINGS Exacerbation of gout following therapy with probenecid may occur; in such cases colchicine or other appropriate therapy is advisable. |
| Indomethacin | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Ketamine | drug interactions | In addition, ketamine and thiopental anesthesia were significantly prolonged in rats receiving probenecid. |
| Ketoprofen | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Lorazepam | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Meclofenamate | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Methotrexate | drug interactions | In animals and in humans, probenecid has been reported to increase plasma concentrations of methotrexate (see WARNINGS ). |
| Naproxen | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Pyrazinamide | drug interactions | The uricosuric action of probenecid is also antagonized by pyrazinamide. |
| Rifampin | drug interactions | These include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin. |
| Sulindac | drug interactions | Probenecid given concomitantly with sulindac had only a slight effect on plasma sulfide levels, while plasma levels of sulindac and sulfone were increased. |
| Theophylline | drug interactions | Falsely high readings for theophylline have been reported in an in vitro study, using the Schack and Waxler technique, when therapeutic concentrations of theophylline and probenecid were added to human plasma. |
Other labels that name probenecid
- Acetaminophen and oxycodone
- Amoxicillin
- Ampicillin and sulbactam
- Aspirin and butalbital and caffeine
- Aspirin, butalbital, caffeine and codeine
- Avibactam and aztreonam
- Avibactam and ceftazidime
- Baricitinib
- Bromocriptine
- Bumetanide
- Cabozantinib
- Captopril and hydrochlorothiazide
- Cefazolin
- Cefdinir
- Cefpodoxime
- Cefuroxime
- Cephalexin
- Cidofovir
- Cilastatin and imipenem
- Deferiprone
- Dicloxacillin
- Ertapenem
- Famciclovir
- Ganciclovir
- Glimepiride
- Glipizide
- Glyburide
- Glycerol phenylbutyrate
- Ketorolac
- Levetiracetam
- Meropenem
- Nitrofurantoin
- Oxacillin
- Penicillin g
- Penicillin g benzathine
- Piperacillin and tazobactam
- Pralatrexate
- Salicylic acid
- Seladelpar lysine
- Sodium benzoate and sodium phenylacetate
- Sodium phenylbutyrate
- Torsemide
- Valganciclovir
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
What do FAERS reports show for probenecid?
The FDA Adverse Event Reporting System holds 1,173 reports that list probenecid among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 167 are coded as a death and 409 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as probenecid?
3 other medicines are given the same way (oral) and in the same FDA class as probenecid or labeled mainly for the same use (gout), the same class first. Gout lists all 8 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Allopurinol | Gout | 42 labelers | $0.0315 per tablet 100 mg tablet | A presentation being discontinued |
| Colchicine | Gout | 30 labelers | $0.122 per tablet 0.6 mg tablet | No current entry |
| Febuxostat | Gout | 23 labelers | $0.191 per tablet 40 mg tablet | No current entry |
Every medicine labeled for the same conditions as probenecid
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to probenecid
- 3 medicines for the same use
- Probenecid side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other