Prescription medication · Nonsteroidal Anti-Inflammatory Drug (NSAID)
oxaprozin
Also sold as Daypro. This medicine can help with the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
Data updated 2026-05-15
- 2,050
- FDA reportsRarely reported
- 15
- InteractionsSeveral interactions
- In shortage
- FDA status
What the data shows
oxaprozin (Daypro) is a prescription Nonsteroidal Anti-Inflammatory Drug (NSAID), among the least-reported drugs the FDA tracks (2,050 FDA reports), with 15 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
oxaprozin (Daypro) is a prescription Nonsteroidal Anti-Inflammatory Drug (NSAID). This medicine can help with the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
Oxaprozin (Daypro) is a nonsteroidal anti-inflammatory drug (NSAID). It helps to reduce pain and swelling.
Verify with FDA → · CMS NADAC pricing →
Drug Shortage Alert
oxaprozin is currently listed as to be discontinued by the FDA. Affected manufacturer: Hospira, Inc., a Pfizer Company.
View all drug shortages →Drug Pricing (NADAC)
Generic Price
$0.45/unit
Generic Available
Yes (3 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine can help with the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
Common side effects
Constipation, Diarrhea, Upset stomach
Key warnings
NSAIDs like oxaprozin can increase your risk of heart problems like heart attack and stroke.
The sections below are summarized in plain English from oxaprozin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Oxaprozin works by reducing substances in the body that cause pain and swelling. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain.
How to Take It
Take oxaprozin once a day by mouth. The usual dose for adults is 1,200 mg (four 300 mg capsules). Children's doses are based on their weight, so follow your doctor's instructions carefully. Your doctor may adjust your dose to find what works best for you.
This is a plain-language summary of oxaprozin's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Taking oxaprozin after 20 weeks of pregnancy may harm your baby. Avoid taking this medicine after 30 weeks of pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant.
This is a plain-language summary of oxaprozin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of oxaprozin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Keep the bottle closed tightly and store it at room temperature.
Side Effects (from patient reports)
Based on 2,050 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for oxaprozin, by number of reports
- Allergic reaction to the drug
Allergic reaction to the drug
386 reports
- Pain 151
Pain
151 reports
- Feeling sick to your stomach 134
Feeling sick to your stomach
134 reports
- Headache 104
Headache
104 reports
- Joint pain 103
Joint pain
103 reports
- Long-term kidney disease 103
Long-term kidney disease
103 reports
- Tiredness 103
Tiredness
103 reports
- Shortness of breath 92
Shortness of breath
92 reports
- Feeling lightheaded 88
Feeling lightheaded
88 reports
- Feeling sad or hopeless 85
Feeling sad or hopeless
85 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for oxaprozin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where oxaprozin sits
oxaprozin has more FDA adverse-event reports than 13% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is oxaprozin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 2,050 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2003–2025.
Total Reports
2,050
Reports Mentioning Death
80
3.9% of reports — not proof of cause
Hospitalization Reports
475
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DRUG HYPERSENSITIVITY | 386 |
| 3 | PAIN | 151 |
| 4 | NAUSEA | 134 |
| 5 | HEADACHE | 104 |
| 6 | ARTHRALGIA | 103 |
| 7 | CHRONIC KIDNEY DISEASE | 103 |
| 8 | FATIGUE | 103 |
| 9 | DYSPNOEA | 91 |
| 10 | DIZZINESS | 88 |
| 11 | DEPRESSION | 85 |
| 12 | PAIN IN EXTREMITY | 82 |
| 13 | RENAL FAILURE | 80 |
| 14 | RASH | 76 |
| 15 | HYPERTENSION | 74 |
| 16 | BACK PAIN | 73 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
NSAIDs like oxaprozin can increase your risk of heart problems like heart attack and stroke. This risk can happen early in treatment and may increase with longer use. You should not take this medicine if you are having heart bypass surgery. NSAIDs also increase the risk of stomach and intestine problems like bleeding and ulcers, which can be fatal. Older adults and people with a history of stomach ulcers are at higher risk.
Known Drug Interactions
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Mechanism: This pain reliever can interfere with how your water pill works to remove salt and fluid from your body. This can make the water pill less effective and might hurt your kidneys.
What to do: Your doctor should check your kidney function regularly while you are taking these medicines. Watch for signs of swelling or weight gain from fluid buildup.
Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction) because NSAID administration may result in increased plasma levels of methotrexate, especially in patients receiving high doses of methotrexate. Intervention: During concomitant use of COXANTO and methotrexate, monitor patients for methotrexate toxicity.
Mechanism: Oxaprozin can cause methotrexate to build up in your blood to dangerous levels by making it harder for your body to clear the drug. This increases the risk of serious side effects like low blood cell counts or kidney problems.
What to do: Your doctor should monitor you closely for signs of methotrexate toxicity while you are taking both medications.
NSAIDs and Salicylates Clinical Impact: Concomitant use of oxaprozin with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [ see Warnings and Precautions (5.2) ] .
Mechanism: Taking two similar pain relievers together increases the risk of stomach damage without providing any extra pain relief. This can lead to serious issues like stomach ulcers or bleeding.
What to do: Avoid taking these two medications at the same time to prevent unnecessary damage to your digestive system.
Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline,...
Mechanism: Oxaprozin belongs to a group of drugs that can increase the risk of bleeding when paired with warfarin. This happens because both drugs make it much harder for the body to form a clot.
What to do: Your doctor should monitor your blood clotting time closely if you take both medications. Watch for signs of bleeding, such as blood in your urine or gums that bleed easily.
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
Mechanism: Both drugs belong to the same family of medicines called NSAIDs, and taking them together is like taking a double dose. This increases the risk of side effects like stomach ulcers and kidney problems without providing extra pain relief.
What to do: Avoid taking these two medications together. Talk to your doctor about using only one type of NSAID to manage your symptoms safely.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I take oxaprozin with aspirin?
What should I do if I experience heartburn while taking oxaprozin?
Can oxaprozin affect my blood pressure?
Is it safe to take oxaprozin if I have kidney problems?
Can oxaprozin cause allergic reactions?
How long does it take for oxaprozin to start working?
Can I drink alcohol while taking oxaprozin?
Does oxaprozin interact with other medications?
Can oxaprozin cause weight gain?
What are the symptoms of a stomach ulcer caused by oxaprozin?
What are the common side effects of oxaprozin?
Does oxaprozin interact with other medications?
What drug class is oxaprozin?
Is oxaprozin safe during pregnancy?
Is oxaprozin currently in shortage?
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What the FDA Data Shows for oxaprozin
The FDA label for oxaprozin (sold under brand names such as Daypro) classifies it as a prescription-only medication in the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. This medicine can help with the symptoms of osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Official labeling lists 5 commonly reported side effects, including Constipation, Diarrhea, Upset stomach.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 2,050 voluntary reports. The database also lists 15 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.45.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC). Shortage status: FDA Drug Shortages Database.
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: October 6, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages