glycopyrrolate/formoterol
Brand names: Bevespi Aerosphere
Bevespi Aerosphere is a medicine that helps people with COPD breathe easier. It contains two medicines that work together to open airways.
What it does
Bevespi Aerosphere is used to help manage chronic obstructive pulmonary disease (COPD).
Common side effects
Cough, Urinary tract infection
Key warnings
LABA medicines like formoterol, when used alone for asthma, increase the risk of serious asthma problems.
How It Works
This medicine combines two drugs: glycopyrrolate and formoterol. Glycopyrrolate is an anticholinergic that relaxes the muscles around your airways. Formoterol is a LABA that also relaxes airway muscles, helping you breathe better.
How to Take It
Use this medicine exactly as your doctor tells you. Take two puffs twice a day, once in the morning and once in the evening. Do not take more than two puffs twice a day. Make sure to prime the inhaler before using it for the first time by spraying it 4 times into the air, away from your face, shaking well before each spray. If you haven't used the inhaler for more than 7 days, re-prime it by spraying it 2 times into the air, away from your face, shaking well before each spray.
Pregnancy & Breastfeeding
It is not known if Bevespi Aerosphere will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if this medicine passes into breast milk. Talk to your doctor about the best way to feed your baby if you are using Bevespi Aerosphere.
Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Storage
Store Bevespi Aerosphere at room temperature, away from heat and direct sunlight. Throw away the inhaler when the dose indicator shows zero or 3 months after removing it from the foil pouch, whichever comes first.
Side Effects (from patient reports)
Based on 5,420 FDA adverse event reports.
Serious Warnings
LABA medicines like formoterol, when used alone for asthma, increase the risk of serious asthma problems. Bevespi Aerosphere is only for COPD, not asthma. Do not use Bevespi Aerosphere if you have asthma.
Known Drug Interactions
May potentiate effect of formoterol fumarate on cardiovascular system. ( 7.6 ) 7.1 Adrenergic Drugs If additional adrenergic drugs are to be administered by any route, they should be used with caution because the sympathetic effects of formoterol, a component of BEVESPI AEROSPHERE, may be potentiated [see Warnings and Precautions (5.3) ] . 7.2 Xanthine Derivatives, Steroids, or Diuretics Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate any hypokalemic effect of beta 2 adrenergic agonists such as formoterol, a component of BEVESPI AEROSPHERE.
Mechanism: Taking two drugs that work the same way can cause a stronger effect on your heart and nervous system. This happens because both drugs stimulate the same receptors in your body.
What to do: Use this combination with caution. Your doctor may need to monitor your heart rate and blood pressure more closely.
Common Questions
What should I do if Bevespi Aerosphere doesn't seem to be working?
Can I use Bevespi Aerosphere for sudden breathing problems?
Can I use Bevespi Aerosphere if I have asthma?
How will I know when my inhaler is empty?
Can I use a spacer with Bevespi Aerosphere?
What if I get Bevespi Aerosphere in my eyes?
Can I take other medicines with Bevespi Aerosphere?
How often should I clean my Bevespi Aerosphere inhaler?
Is it okay to share my Bevespi Aerosphere inhaler with someone else?
What should I do if I have trouble using the inhaler?
What are the common side effects of glycopyrrolate/formoterol?
Does glycopyrrolate/formoterol interact with other medications?
What drug class is glycopyrrolate/formoterol?
Is glycopyrrolate/formoterol safe during pregnancy?
Related Medications in LAMA / LABA Combination
Other drugs grouped near glycopyrrolate/formoterol — same-class peers and common alternatives.
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albuterol/ipratropium
Combivent Respimat, DuoNeb
Combivent Respimat is a combination medicine that helps open your airways.
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beclomethasone
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Qvar Redihaler is an inhaled medicine that helps control asthma symptoms.
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benralizumab
Fasenra
Fasenra is a medicine that can help treat severe asthma and EGPA.
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Compare glycopyrrolate/formoterol vs aclidinium side-by-side →
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What the FDA Data Shows for glycopyrrolate/formoterol
The FDA label for glycopyrrolate/formoterol (sold under brand names such as Bevespi Aerosphere) classifies it as a prescription-only medication in the LAMA / LABA Combination class. Bevespi Aerosphere is used to help manage chronic obstructive pulmonary disease (COPD). Official labeling lists 2 commonly reported side effects, including Cough, Urinary tract infection.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 5,420 voluntary reports. The database also lists 1 documented drug interaction derived from FDA labeling, with the top-flagged interaction rated moderate severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: March 24, 2023
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages