trospium
Brand names: Sanctura
Trospium chloride (Sanctura) helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom often.
Drug Pricing (NADAC)
Generic Price
$0.26/unit
Generic Available
Yes (10 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine treats overactive bladder (OAB).
Common side effects
Dry mouth, Constipation, Headache
Key warnings
Trospium chloride should be used carefully if you have a bladder blockage or stomach problems, as it can cause you to not be able to urinate or have gastric retention.
How It Works
Trospium chloride blocks the action of a chemical called acetylcholine. This chemical can cause bladder muscles to squeeze too much. By blocking acetylcholine, the medicine helps the bladder relax, reducing the urge to urinate.
How to Take It
Take one 20 mg tablet two times a day. Take it with water on an empty stomach. This means taking it at least 1 hour before a meal. If you have kidney problems, your doctor may tell you to take 20 mg once a day at bedtime. If you are over 75, your doctor may lower your dose to 20mg once daily.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant or plan to become pregnant. This medicine should only be used during pregnancy if clearly needed. It is not known if this medicine passes into breast milk, so talk to your doctor if you are breastfeeding.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Storage
Store at room temperature between 68°F and 77°F.
Serious Warnings
Trospium chloride should be used carefully if you have a bladder blockage or stomach problems, as it can cause you to not be able to urinate or have gastric retention. This medicine may cause swelling of the face, lips, tongue, or throat, which can be life-threatening. Get medical help right away if this happens. Trospium may cause sleepiness, so be careful driving or using machines until you know how it affects you.
Known Drug Interactions
( 7.2 ) Concomitant use with metformin immediate release tablets reduced exposure and peak concentration of trospium. 7.4 Metformin Co-administration of 500 mg metformin immediate release tablets twice daily with trospium chloride 60 mg extended release reduced the steady-state systemic exposure of trospium by approximately 29% for mean AUC 0-24 and by 34% for mean C max [ see Clinical Pharmacology (12.3) ].
Mechanism: Metformin lowers the amount of trospium that gets into your bloodstream. This means there is less medicine available in your body to do its job.
What to do: Your doctor may need to change your dose of trospium to make sure it still works for you.
7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, morphine, vancomycin, and tenofovir).
Mechanism: Both drugs leave the body through the same path in the kidneys. This can cause the drugs to build up or change how they work because they are competing to get out.
What to do: Your healthcare provider should watch you closely for any new side effects or changes in your symptoms.
7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, morphine, vancomycin, and tenofovir).
Mechanism: These medicines are cleared out of the body by the same part of the kidneys. Taking them together might change how much of each drug stays in your system.
What to do: Your doctor may need to monitor your blood levels or symptoms to ensure both drugs are working safely.
7 DRUG INTERACTIONS Concomitant use with digoxin did not affect the pharmacokinetics of either drug. ( 7.4 ) 7.1 Digoxin Concomitant use of trospium chloride tablets and digoxin did not affect the pharmacokinetics of either drug [ see Clinical Pharmacology (12.3) ]. 7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, mor...
Mechanism: Research shows that these two drugs do not change how the other is handled by the body. They can be processed at the same time without interfering with each other.
What to do: You can typically take these medications together without any special dose changes.
Common Questions
Can I take this medicine with food?
What should I do if I get a very dry mouth?
Can I drive while taking this medicine?
Is it okay to take this with my other medications?
What if I have narrow-angle glaucoma?
Can this medicine cause allergic reactions?
What if I have kidney problems?
Can I drink alcohol while taking this medicine?
How long will it take for this medicine to work?
What do the tablet markings mean?
What are the common side effects of trospium?
Does trospium interact with other medications?
What drug class is trospium?
Is trospium safe during pregnancy?
Has trospium been recalled?
Active Recalls
Failed Tablets/Capsules specifications; missing/broken/extra tablets within the capsules
Padagis US LLC
Related Medications in Anticholinergic (Overactive Bladder)
Other drugs grouped near trospium — same-class peers and common alternatives.
alfuzosin
Uroxatral
Alfuzosin is a medicine that helps men with enlarged prostate glands.
Compare with trospium →
bethanechol
Urecholine
Bethanechol helps you to urinate if you have trouble emptying your bladder.
Compare with trospium →
darifenacin
Enablex
Darifenacin (Enablex) is a medicine that helps control an overactive bladder.
Compare with trospium →
dutasteride
Avodart
Dutasteride and tamsulosin hydrochloride capsules contain two medicines to treat enlarged prostate in men.
Compare with trospium →
dutasteride/tamsulosin
Jalyn
This medicine combines two drugs to treat enlarged prostate in men.
Compare with trospium →
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
Related Health & Safety Data
🩺 Find a Doctor
Search prescribers for Anticholinergic (Overactive Bladder)
🏨 Hospital Quality
CMS hospital ratings, safety scores & patient outcomes
💊 Supplement Data
NIH DSLD — check supplement ingredients & label claims
🍽️ Food Safety Alerts
FDA recalls, inspections & outbreak investigations
⚠️ Product Recalls
FDA, CPSC & NHTSA recall search
💉 Procedure Costs
Medicare procedure pricing for 9,297 procedures
Save on trospium
Compare prices and find discounts at pharmacies near you. Free coupons can save up to 80% on prescriptions.
Disclosure: This link may earn us a commission at no extra cost to you. See our terms.
What the FDA Data Shows for trospium
The FDA label for trospium (sold under brand names such as Sanctura) classifies it as a prescription-only medication in the Anticholinergic (Overactive Bladder) class. This medicine treats overactive bladder (OAB). Official labeling lists 3 commonly reported side effects, including Dry mouth, Constipation, Headache.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 4 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.26.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: December 19, 2024
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages