Prescription medication · Anticholinergic (Overactive Bladder)
trospium
Also sold as Sanctura. This medicine treats overactive bladder (OAB).
Data updated 2026-05-15
- 4
- InteractionsFew interactions
- 1
- Recall record
What the data shows
trospium (Sanctura) is a prescription Anticholinergic (Overactive Bladder), with 4 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
trospium (Sanctura) is a prescription Anticholinergic (Overactive Bladder). This medicine treats overactive bladder (OAB).
Trospium chloride (Sanctura) helps control an overactive bladder. It reduces the feeling of needing to go to the bathroom often.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.26/unit
Generic Available
Yes (10 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine treats overactive bladder (OAB).
Common side effects
Dry mouth, Constipation, Headache
Key warnings
Trospium chloride should be used carefully if you have a bladder blockage or stomach problems, as it can cause you to not be able to urinate or have gastric retention.
The sections below are summarized in plain English from trospium's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Trospium chloride blocks the action of a chemical called acetylcholine. This chemical can cause bladder muscles to squeeze too much. By blocking acetylcholine, the medicine helps the bladder relax, reducing the urge to urinate.
Serious Warnings
Trospium chloride should be used carefully if you have a bladder blockage or stomach problems, as it can cause you to not be able to urinate or have gastric retention. This medicine may cause swelling of the face, lips, tongue, or throat, which can be life-threatening. Get medical help right away if this happens. Trospium may cause sleepiness, so be careful driving or using machines until you know how it affects you.
Known Drug Interactions
( 7.2 ) Concomitant use with metformin immediate release tablets reduced exposure and peak concentration of trospium. 7.4 Metformin Co-administration of 500 mg metformin immediate release tablets twice daily with trospium chloride 60 mg extended release reduced the steady-state systemic exposure of trospium by approximately 29% for mean AUC 0-24 and by 34% for mean C max [ see Clinical Pharmacology (12.3) ].
Mechanism: Metformin lowers the amount of trospium that gets into your bloodstream. This means there is less medicine available in your body to do its job.
7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, morphine, vancomycin, and tenofovir).
Mechanism: Both drugs leave the body through the same path in the kidneys. This can cause the drugs to build up or change how they work because they are competing to get out.
7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium, morphine, vancomycin, and tenofovir).
Mechanism: These medicines are cleared out of the body by the same part of the kidneys. Taking them together might change how much of each drug stays in your system.
7 DRUG INTERACTIONS Concomitant use with digoxin did not affect the pharmacokinetics of either drug. ( 7.4 ) 7.1 Digoxin Concomitant use of trospium chloride tablets and digoxin did not affect the pharmacokinetics of either drug [ see Clinical Pharmacology (12.3) ]. 7.2 Drugs Eliminated by Active Tubular Secretion Although demonstrated in a drug-drug interaction study not to affect the pharmacokinetics of digoxin, trospium chloride tablets has the potential for pharmacokinetic interactions with other drugs that are eliminated by active tubular secretion (e.g., procainamide, pancuronium,...
Mechanism: Research shows that these two drugs do not change how the other is handled by the body. They can be processed at the same time without interfering with each other.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take this medicine with food?
What should I do if I get a very dry mouth?
Can I drive while taking this medicine?
Is it okay to take this with my other medications?
What if I have narrow-angle glaucoma?
Can this medicine cause allergic reactions?
What if I have kidney problems?
Can I drink alcohol while taking this medicine?
How long will it take for this medicine to work?
What do the tablet markings mean?
What are the common side effects of trospium?
Does trospium interact with other medications?
What drug class is trospium?
What pregnancy or breastfeeding source fields are listed for trospium?
Has trospium been recalled?
Active Recalls
Failed Tablets/Capsules specifications; missing/broken/extra tablets within the capsules
Padagis US LLC
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Medication Guides
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What the FDA Data Shows for trospium
The FDA label for trospium (sold under brand names such as Sanctura) classifies it as a prescription-only medication in the Anticholinergic (Overactive Bladder) class. This medicine treats overactive bladder (OAB). Official labeling lists 3 commonly reported side effects, including Dry mouth, Constipation, Headache.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. The database also lists 4 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.26.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history (currently 1 recall record on file), and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: December 19, 2024
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages