Prescription medicine

Magnesium sulfate and potassium sulfate and sodium sulfate Brand names: Suprep; first approved as Suprep Bowel Prep

Magnesium sulfate and potassium sulfate and sodium sulfate (Suprep) is a prescription medicine with an FDA approval on record since 2010. FDA's NDC Directory lists it from 9 generic labelers, and pharmacies paid $0.0901 per mL (Sod sul-potass sul-mag sul solution) in the October 7, 2026 NADAC survey.

Generic listed

Check it at the source: the magnesium sulfate and potassium sulfate and sodium sulfate FDA label on DailyMed (effective June 30, 2026, Bionpharma Inc.,); the NDA 22372 record on Drugs@FDA; every magnesium sulfate and potassium sulfate and sodium sulfate label on DailyMed.

Highlights of the record

FDA label of June 30, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026

Used for

From the label: indications and usage
Sodium sulfate, potassium sulfate, and magnesium sulfate oral solution is indicated for cleansing of the colon as a preparation for colonoscopy in adult patients.

Forms and strengths

13.13 g/133.1ml / 2.35 g/133.1ml / 1.2 g/133.1ml
17.5 g/ml / 3.13 g/ml / 1.6 g/ml
17.5 g/177ml / 3.13 g/177ml / 1.6 g/177ml

Solution; solution (concentrate).

On the market

Earliest approval on file: August 5, 2010 Suprep Bowel Prep Kit, Azurity; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals: 8 first February 23, 2017; 8 with a marketed status in Drugs@FDA
Labelers listed (NDC): 13 of which 9 under generic applications, 4 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC): $0.0901 per mL Sod sul-potass sul-mag sul solution
Shortage (FDA): No current entry
Recalls by its makers (FDA): No recall recorded
FAERS reports: 4,353 through July 30, 2026

What is magnesium sulfate and potassium sulfate and sodium sulfate used for?

From the label: indications and usage
Sodium sulfate, potassium sulfate, and magnesium sulfate oral solution is indicated for cleansing of the colon as a preparation for colonoscopy in adult patients. Pediatric use information is approved for Braintree Laboratories, Inc.'s SUPREP BOWEL PREP KIT (sodium sulfate, potassium sulfate, and magnesium sulfate) oral solution. However, due to Braintree Laboratories, Inc.'s marketing exclusivity rights, this drug product is not labeled with that pediatric information. Sodium sulfate, potassium sulfate, and magnesium sulfate oral solution is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adult patients.

FDA pharmacologic class: Calculi Dissolution Agent, Osmotic Laxative and Potassium Salt.

Source: FDA drug label (sodium sulfate, potassium sulfate, and magnesium sulfate), Bionpharma Inc.,, effective June 30, 2026 (SPL set 31d13799-0931-7735-e063-6294a90a6d02), via openFDA; the full label on DailyMed

Is there a generic for magnesium sulfate and potassium sulfate and sodium sulfate (Suprep)?

The FDA approved the first generic magnesium sulfate and potassium sulfate and sodium sulfate on February 23, 2017. 8 generic applications are approved; 8 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale. Drugs@FDA also holds 1 tentative approval: the FDA found the generic approvable, but patents or exclusivity keep it from final approval for now.

FDA's NDC Directory lists magnesium sulfate and potassium sulfate and sodium sulfate from 9 labelers under a generic (ANDA) application and from 4 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

2010 earliest approval on file
2017 first generic approved

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What do pharmacies pay for magnesium sulfate and potassium sulfate and sodium sulfate (Suprep)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.0901 per mL (Sod sul-potass sul-mag sul solution), down 50% from $0.181 on October 8, 2025. The survey records the price, not the reason for a change; large moves often follow a new generic or a list-price change. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

Sod sul-potass sul-mag sul solution (generic)
Suprep bowel prep kit (brand)

$0.325

$0.0901

January 2024October 2026

NADAC per unit, October 7, 2026
Strength and form	Brand or generic	Pharmacy cost	30 tablets, or one pen or vial	12-month change
Sod sul-potass sul-mag sul solution	Generic	$0.0901 per mL	n/a	-50%
Suprep bowel prep kit	Brand	$0.325 per mL	n/a	+0.1%

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What does the magnesium sulfate and potassium sulfate and sodium sulfate label say about other medicines?

The magnesium sulfate and potassium sulfate and sodium sulfate label names 5 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Medicine named	Section	What the label says
Bisacodyl	drug interactions	Avoid use of stimulant laxatives (e.g., bisacodyl, sodium picosulfate) while taking sodium sulfate, potassium sulfate, and magnesium sulfate oral solution [see Warnings and Precautions (5.5) ].
Chlorpromazine	drug interactions	Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium sulfate, potassium sulfate, and magnesium sulfate oral solution to avoid chelation with magnesium.
Digoxin	drug interactions	Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium sulfate, potassium sulfate, and magnesium sulfate oral solution to avoid chelation with magnesium.
Penicillamine	drug interactions	Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium sulfate, potassium sulfate, and magnesium sulfate oral solution to avoid chelation with magnesium.
Tetracycline	drug interactions	Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium sulfate, potassium sulfate, and magnesium sulfate oral solution to avoid chelation with magnesium.

Check magnesium sulfate and potassium sulfate and sodium sulfate against other medicines

What do FAERS reports show for magnesium sulfate and potassium sulfate and sodium sulfate?

The FDA Adverse Event Reporting System holds 4,353 reports that list magnesium sulfate and potassium sulfate and sodium sulfate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 31 are coded as a death and 223 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

The most reported reactions

Vomiting (named in the label)1,637
Nausea (named in the label)1,147
Abdominal Distension (named in the label)393
Drug Ineffective (a use or a product term, not a reaction)380
Abdominal Pain (named in the label)377
Headache (named in the label)371
Dizziness (named in the label)226
Abdominal Pain Upper194

Side effects: the label's list and every FAERS reaction

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What next?

Other calculi dissolution agents: the pharmacologic class, with prices and generics
Magnesium sulfate and potassium sulfate and sodium sulfate side effects: the label's list beside FAERS reports
Check an interaction: what two or more labels say about each other