Prescription medicine
Prucalopride Brand names: Motegrity
Prucalopride (Motegrity) is a prescription medicine with an FDA approval on record since 2018. FDA's NDC Directory lists it from 18 generic labelers, and pharmacies paid $0.639 per prucalopride 1 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the prucalopride FDA label on DailyMed (effective July 17, 2025, Takeda Pharmaceuticals America, Inc.); the NDA 210166 record on Drugs@FDA; every prucalopride label on DailyMed.
Highlights of the record
FDA label of July 17, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageMOTEGRITY ® is indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
Forms and strengths
- 1 mg
- 2 mg
Film-coated tablet; tablet.
On the market
- Earliest approval on file
- December 14, 2018 Motegrity, Takeda Pharms Usa; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 19 first December 26, 2024; 17 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 19 of which 18 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $0.639 per tablet Prucalopride 1 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 2,617 through July 30, 2026
What is prucalopride used for?
From the label: indications and usageMOTEGRITY ® is indicated for the treatment of chronic idiopathic constipation (CIC) in adults. MOTEGRITY is a serotonin-4 (5-HT 4 ) receptor agonist indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
Conditions named in the indications of prucalopride's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Serotonin-4 Receptor Agonist.
Source: FDA drug label (MOTEGRITY), Takeda Pharmaceuticals America, Inc., effective July 17, 2025 (SPL set bca1e4c6-4b2b-4876-8ab3-654629c4ff1b), via openFDA; the full label on DailyMed
Is there a generic for prucalopride (Motegrity)?
The FDA approved the first generic prucalopride on December 26, 2024. 19 generic applications are approved; 17 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists prucalopride from 18 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 2018 earliest approval on file
- 2024 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for prucalopride (Motegrity)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.639 per Prucalopride 1 mg tablet, down 95% from $12.61 on October 8, 2025. The survey records the price, not the reason for a change; large moves often follow a new generic or a list-price change. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Prucalopride 2 mg tablet (generic)
- Motegrity 1 mg tablet (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Prucalopride 1 mg tablet | Generic | $0.639 per tablet | $19.18 | -95% |
| Prucalopride 2 mg tablet | Generic | $0.619 per tablet | $18.57 | -95% |
| Motegrity 1 mg tablet | Brand | $17.73 per tablet many times the lowest per-tablet cost; NADAC records the price, not why | $531.94 | -0.1% |
| Motegrity 2 mg tablet | Brand | $17.75 per tablet many times the lowest per-tablet cost; NADAC records the price, not why | $532.54 | -0.3% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for prucalopride?
The FDA Adverse Event Reporting System holds 2,617 reports that list prucalopride among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 79 are coded as a death and 646 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as prucalopride?
15 other medicines are given the same way (oral) and in the same FDA class as prucalopride or labeled mainly for the same use (constipation), the same class first. Constipation lists all 20 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Docusate | Constipation | none listed | $0.0276 per unit 100 mg softgel | No current entry |
| Sennosides | Constipation | none listed | $0.0258 per tablet 8.6 mg tablet | No current entry |
| Polyethylene glycol 3350 | Constipation | 73 labelers | $0.0286 per gram 3350 powd | No current entry |
| Bisacodyl | Constipation | none listed | $0.0441 per tablet 5 mg tablet | No current entry |
| Magnesium hydroxide | Constipation | none listed | $0.0095 per mL Milk of magnesia suspension | No current entry |
| Magnesium citrate | Constipation | none listed | $0.0066 per mL Magnesium citrate solution | No current entry |
| Lubiprostone | Constipation | 10 labelers | $0.651 per capsule 24 mcg capsule | No current entry |
| Psyllium husk | Constipation | none listed | n/a | No current entry |
Every medicine labeled for the same conditions as prucalopride
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does prucalopride compare with medicines for the same use?
2 side-by-side pages set prucalopride beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to prucalopride
- 15 medicines for the same use
- Prucalopride side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other