fluconazole vs triazolam
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Side-by-side comparison of fluconazole and triazolam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Triazolam: Fluconazole increases the AUC of triazolam (single dose) by approximately 50%, C max by 20% to 32%, and increases t ½ by 25% to 50% due to the inhibition of metabolism of triazolam. Dosage adjustments of triazolam may be necessary.
Diflucan
Halcion
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Triazolam (Halcion) is a medication used for the short-term treatment of insomnia. It belongs to a class of drugs called benzodiazepines, which help you fall asleep.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Triazolam is used to treat insomnia in adults. Insomnia is when you have trouble falling asleep or staying asleep. This medicine is only for short-term use, usually for 7 to 10 days.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Triazolam works by slowing down activity in the brain. This helps you to relax and fall asleep. It affects certain chemicals in your brain called neurotransmitters.
- • Headache
- • Nausea
- • Abdominal pain
- • Drowsiness
- • Headache
- • Dizziness
- • Nervousness
- • Light-headedness
- Pyrexia 4,121
- Nausea 3,697
- Diarrhoea 3,538
- Fatigue 3,151
- Pain 3,123
- Drug Abuse 519
- Sopor 402
- Nausea 352
- Overdose 350
- Fall 315
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Taking triazolam with opioid pain medicines can cause very serious problems, including slowed or stopped breathing, coma, and death. Because of these risks, doctors will only prescribe opioid pain medicines with triazolam when other treatment options are not sufficient. Do not misuse this medicine. Misuse can lead to addiction, overdose, or death. Stopping triazolam suddenly can cause dangerous withdrawal symptoms. Talk to your doctor before stopping this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Taking triazolam late in pregnancy may cause sedation or withdrawal symptoms in the newborn. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of taking triazolam. A registry exists to track outcomes in women who take psychiatric medications, including triazolam, during pregnancy.
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How to Read This fluconazole vs triazolam Comparison
fluconazole is classified in the Azole Antifungal drug class, while triazolam sits within the Benzodiazepine (Hypnotic) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,630 submissions while triazolam has 1,938. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole stops your body from breaking down triazolam normally, which can make the drug's effects last longer and feel stronger.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluconazole or triazolam.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.