diltiazem vs triazolam
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Side-by-side comparison of diltiazem and triazolam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Benzodiazepines : Studies showed that diltiazem increased the AUC of midazolam and triazolam by 3- to 4-fold and the C max by 2-fold, compared to placebo. The elimination half-life of midazolam and triazolam also increased (1.5- to 2.5-fold) during coadministration with diltiazem. These pharmacokinetic effects seen during diltiazem coadministration can result in increased clinical effects (e.g., prolonged sedation) of both midazolam and triazolam.
Diltiazem is a medicine that helps lower high blood pressure and prevent chest pain. It belongs to a class of drugs called calcium channel blockers.
Triazolam (Halcion) is a medication used for the short-term treatment of insomnia. It belongs to a class of drugs called benzodiazepines, which help you fall asleep.
Diltiazem is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. Diltiazem also helps manage chronic stable angina (chest pain) and angina caused by spasms in the heart's blood vessels.
Triazolam is used to treat insomnia in adults. Insomnia is when you have trouble falling asleep or staying asleep. This medicine is only for short-term use, usually for 7 to 10 days.
Diltiazem works by relaxing blood vessels, which lowers blood pressure. It also reduces the heart's workload, which can prevent chest pain. This medicine blocks calcium from entering heart and blood vessel cells.
Triazolam works by slowing down activity in the brain. This helps you to relax and fall asleep. It affects certain chemicals in your brain called neurotransmitters.
- • Swelling in your ankles or feet
- • Headache
- • Dizziness
- • Slow heart rate
- • Constipation
- • Drowsiness
- • Headache
- • Dizziness
- • Nervousness
- • Light-headedness
- Dyspnoea 3,202
- Fatigue 2,638
- Nausea 2,372
- Pain 2,365
- Dizziness 2,091
- Drug Abuse 519
- Sopor 402
- Nausea 352
- Overdose 350
- Fall 315
Diltiazem can interact with other heart medications. Tell your doctor if you take beta-blockers or digoxin. Using diltiazem with these drugs can cause heart problems. Your doctor may need to adjust your dosages.
Taking triazolam with opioid pain medicines can cause very serious problems, including slowed or stopped breathing, coma, and death. Because of these risks, doctors will only prescribe opioid pain medicines with triazolam when other treatment options are not sufficient. Do not misuse this medicine. Misuse can lead to addiction, overdose, or death. Stopping triazolam suddenly can cause dangerous withdrawal symptoms. Talk to your doctor before stopping this medicine.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if diltiazem will harm your unborn baby. Diltiazem passes into breast milk, so talk to your doctor about breastfeeding while taking this medicine.
Taking triazolam late in pregnancy may cause sedation or withdrawal symptoms in the newborn. If you are pregnant or plan to become pregnant, talk to your doctor about the risks and benefits of taking triazolam. A registry exists to track outcomes in women who take psychiatric medications, including triazolam, during pregnancy.
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How to Read This diltiazem vs triazolam Comparison
diltiazem is classified in the Calcium Channel Blocker drug class, while triazolam sits within the Benzodiazepine (Hypnotic) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diltiazem has 12,668 submissions while triazolam has 1,938. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to diltiazem slows down how fast your body gets rid of triazolam, which can make the sedative effects last much longer.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diltiazem or triazolam.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.