Sertraline and Paroxetine Interaction
Drug interaction information between Sertraline and Paroxetine.
Sertraline and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sertraline and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can cause an additive increase in serotonin levels because they both work in a similar way.
FDA Label Information
If concomitant treatment with sumatriptan and an SSRI (e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Sertraline's 34. In the minor band specifically: Sertraline has 31 (also Fluoxetine, Citalopram, Atenolol, Sumatriptan); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Sertraline and Paroxetine?
Taking these drugs together can cause an additive increase in serotonin levels because they both work in a similar way.
Paroxetine carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Sertraline's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Atenolol
- Sumatriptan
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.