Sertraline and Phenelzine Interaction
Drug interaction information between Sertraline and Phenelzine.
Sertraline and Phenelzine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sertraline and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase a chemical in your brain called serotonin. Taking them together can cause dangerously high levels of serotonin, which can be life-threatening.
FDA Label Information
Drug Interactions In patients receiving nonselective monoamine oxidase (MAO) inhibitors in combination with serotoninergic agents (e.g., dexfenfluramine, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, venlafaxine) there have been reports of serious, sometimes fatal, reactions.
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Fluoxetine minor
- Citalopram minor
- Paroxetine minor
Phenelzine Also Interacts With
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
- Desvenlafaxine moderate
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Phenelzine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Phenelzine's 27. In the moderate band specifically: Sertraline has 2 (also Aspirin); Phenelzine has 11 (also Fluoxetine, Citalopram, Venlafaxine, Fluvoxamine).
What mechanism field is on file for Sertraline and Phenelzine?
Both of these drugs increase a chemical in your brain called serotonin. Taking them together can cause dangerously high levels of serotonin, which can be life-threatening.
Sertraline carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is moderate · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
Sertraline has 1 major-labeled pair vs Phenelzine's 0. This page itself is in the moderate band, not the major band.
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Fluoxetine
- Citalopram
- Venlafaxine
- Fluvoxamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.