Sertraline and Sumatriptan Interaction
Drug interaction information between Sertraline and Sumatriptan.
Sertraline and Sumatriptan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sertraline and Sumatriptan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can rarely cause a reaction that leads to muscle weakness, overactive reflexes, or loss of coordination.
FDA Label Information
Sumatriptan –There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan. If concomitant treatment with sumatriptan and an SSRI (e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Sumatriptan Also Interacts With
- Norepinephrine minor
- Escitalopram minor
- Fluvoxamine minor
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Sumatriptan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Sumatriptan's 4. In the minor band specifically: Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol); Sumatriptan has 4 (also Norepinephrine, Escitalopram, Fluvoxamine).
What mechanism field is on file for Sertraline and Sumatriptan?
Combining these drugs can rarely cause a reaction that leads to muscle weakness, overactive reflexes, or loss of coordination.
Sertraline carries more major-labeled pairs than Sumatriptan
SPL source-record counts only. This page's band is minor · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Sumatriptan (Triptan (Serotonin 5-HT1 Agonist)).
Sertraline has 1 major-labeled pair vs Sumatriptan's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Sumatriptan
- Norepinephrine
- Escitalopram
- Fluvoxamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.