Sertraline and Fluoxetine Interaction
Drug interaction information between Sertraline and Fluoxetine.
Sertraline and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sertraline and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications increase serotonin levels in the brain, which can lead to an additive effect when taken together.
FDA Label Information
If concomitant treatment with sumatriptan and an SSRI (e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Citalopram minor
- Paroxetine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Sertraline's 34. In the minor band specifically: Sertraline has 31 (also Citalopram, Paroxetine, Atenolol, Sumatriptan); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Sertraline and Fluoxetine?
Both medications increase serotonin levels in the brain, which can lead to an additive effect when taken together.
Fluoxetine carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Sertraline's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Citalopram
- Paroxetine
- Atenolol
- Sumatriptan
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.