Sertraline and Clonazepam Interaction
Drug interaction information between Sertraline and Clonazepam.
Sertraline and Clonazepam have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Sertraline and Clonazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline does not interfere with how your body breaks down or uses clonazepam.
FDA Label Information
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Sertraline Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
- Paroxetine minor
Clonazepam Also Interacts With
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Clonazepam?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Clonazepam's 14. In the major band specifically: Sertraline has 1; Clonazepam has 3 (also Fluoxetine, Felbamate).
What mechanism field is on file for Sertraline and Clonazepam?
Sertraline does not interfere with how your body breaks down or uses clonazepam.
Clonazepam carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is major · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Clonazepam (Benzodiazepine).
Clonazepam has 3 major-labeled pairs vs Sertraline's 1.
1 major · 2 moderate · 31 minor · 34 total
Sertraline has no other major-band peer in this dataset besides Clonazepam.
3 major · 1 moderate · 10 minor · 14 total
- Other major peers for Clonazepam
- Fluoxetine
- Felbamate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.