Sertraline and Aspirin Interaction
Drug interaction information between Sertraline and Aspirin.
Sertraline and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sertraline and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs change how your blood cells work to stop bleeding. Taking them together increases your risk of serious bleeding, especially in your stomach or gut.
FDA Label Information
Drugs that Interfere with Hemostasis (Non-selective NSAIDs, Aspirin, Warfarin, etc.) Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. These studies have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Sertraline Also Interacts With
- Clonazepam major
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
- Paroxetine minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Sertraline's 34. In the moderate band specifically: Sertraline has 2 (also Phenelzine); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone).
What mechanism field is on file for Sertraline and Aspirin?
Both drugs change how your blood cells work to stop bleeding. Taking them together increases your risk of serious bleeding, especially in your stomach or gut.
Aspirin carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is moderate · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Sertraline's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 31 minor · 34 total
- Other moderate peers for Sertraline
- Phenelzine
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.