What the FDA labels say about taking them together
Aspirin and sertraline
Sertraline's FDA label of August 8, 2023 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name sertraline. The sertraline label: “The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the aspirin label say about sertraline?
Aspirin's label (effective September 9, 2025) does not name sertraline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the sertraline label say about aspirin?
Sertraline label, drug interactionsDrugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. Intervention: Inform patients of the increased risk of bleeding associated with the concomitant use of ZOLOFT and antiplatelet agents and anticoagulants. For patients taking warfarin, carefully monitor the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin
Sertraline label, warnings and precautionsIncreased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk.
Source: FDA drug label (Sertraline Hcl, NDA215133), Almatica Pharma LLC, effective August 24, 2023 (SPL set 8c8bcba9-eaeb-aa44-f9ea-b580de55a439), via openFDA
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Sertraline | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once