Sertraline and Atenolol Interaction
Drug interaction information between Sertraline and Atenolol.
Sertraline and Atenolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sertraline and Atenolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline does not change the way atenolol works to control heart rate or blood pressure.
FDA Label Information
Atenolol – Sertraline hydrochloride (100 mg) when administered to 10 healthy male subjects had no effect on the beta-adrenergic blocking ability of atenolol.
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
Frequently Asked Questions
What SPL severity band is on file for Sertraline + Atenolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Atenolol's 14. In the minor band specifically: Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Sumatriptan); Atenolol has 12 (also Clonidine, Amiodarone, Epinephrine, Indomethacin).
What mechanism field is on file for Sertraline and Atenolol?
Sertraline does not change the way atenolol works to control heart rate or blood pressure.
Atenolol carries more major-labeled pairs than Sertraline
SPL source-record counts only. This page's band is minor · classes on file: Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)); Atenolol (Beta-1 Selective Blocker).
Atenolol has 2 major-labeled pairs vs Sertraline's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Sumatriptan
2 major · 0 moderate · 12 minor · 14 total
- Other minor peers for Atenolol
- Clonidine
- Amiodarone
- Epinephrine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.