Atenolol and Epinephrine Interaction
Drug interaction information between Atenolol and Epinephrine.
Atenolol and Epinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atenolol and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atenolol can block the effects of epinephrine, which means the usual dose of epinephrine might not work during a severe allergic reaction.
FDA Label Information
Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction.
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Indomethacin minor
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Atenolol + Epinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Atenolol's 14. In the minor band specifically: Atenolol has 12 (also Clonidine, Amiodarone, Indomethacin, Dutasteride); Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin).
What mechanism field is on file for Atenolol and Epinephrine?
Atenolol can block the effects of epinephrine, which means the usual dose of epinephrine might not work during a severe allergic reaction.
Atenolol carries more major-labeled pairs than Epinephrine
SPL source-record counts only. This page's band is minor · classes on file: Atenolol (Beta-1 Selective Blocker); Epinephrine (Adrenergic Agonist).
Atenolol has 2 major-labeled pairs vs Epinephrine's 1. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 12 minor · 14 total
- Other minor peers for Atenolol
- Clonidine
- Amiodarone
- Indomethacin
- Dutasteride
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.