Atenolol and Theophylline Interaction
Drug interaction information between Atenolol and Theophylline.
Atenolol and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Atenolol and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Atenolol is a beta-blocker that can interfere with how theophylline works to open your airways. It may also slow down the process of your body removing theophylline from your blood.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Atenolol Also Interacts With
- Aspirin major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
- Indomethacin minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Atenolol + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Atenolol's 14. In the major band specifically: Atenolol has 2 (also Aspirin); Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Atenolol and Theophylline?
Atenolol is a beta-blocker that can interfere with how theophylline works to open your airways. It may also slow down the process of your body removing theophylline from your blood.
Theophylline carries more major-labeled pairs than Atenolol
SPL source-record counts only. This page's band is major · classes on file: Atenolol (Beta-1 Selective Blocker); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Atenolol's 2.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.