What the FDA labels say about taking them together
Atenolol and clonidine
Atenolol's FDA label of September 18, 2025 names clonidine in its drug interactions section; clonidine's label does not name atenolol itself but warns about its class (Beta blockers).
Check it at the source: the atenolol FDA label on DailyMed (effective September 18, 2025, Upsher-Smith Laboratories, LLC); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the atenolol label say about clonidine?
Atenolol label, drug interactionsBeta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
Source: FDA drug label (TENORMIN), NDA018240 (Twi Pharms), as published by Upsher-Smith Laboratories, LLC, effective September 18, 2025 (SPL set 6e850b1e-28a4-4ff8-8ed7-bb0b29faa28a), via openFDA; the full label on DailyMed
What does the clonidine label say about atenolol?
Clonidine's label does not name atenolol itself; it warns about its class (Beta blockers):
Clonidine label, drug interactionsMonitor heart rate in patients receiving clonidine concomitantly with agents known to affect sinus node function or AV nodal conduction, e.g. , digitalis, calcium channel blockers and beta-blockers.
Clonidine label, warningsThe likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Atenolol | Clonidine | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0217 per tablet 25 mg tablet | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once