Atenolol and Aspirin Interaction
Drug interaction information between Atenolol and Aspirin.
Atenolol and Aspirin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Atenolol and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Current medical studies do not show a clear way these two drugs interfere with each other when used for heart attacks.
FDA Label Information
Information on concurrent usage of atenolol and aspirin is limited. Data from several studies, i.e., TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta-blockers in the acute myocardial infarction setting.
Atenolol Also Interacts With
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
- Indomethacin minor
Aspirin Also Interacts With
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
- Desvenlafaxine moderate
Frequently Asked Questions
What SPL severity band is on file for Atenolol + Aspirin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Atenolol's 14. In the major band specifically: Atenolol has 2 (also Theophylline); Aspirin has 3 (also Fluoxetine, Ibandronate).
What mechanism field is on file for Atenolol and Aspirin?
Current medical studies do not show a clear way these two drugs interfere with each other when used for heart attacks.
Aspirin carries more major-labeled pairs than Atenolol
SPL source-record counts only. This page's band is major · classes on file: Atenolol (Beta-1 Selective Blocker); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Atenolol's 2.
3 major · 12 moderate · 32 minor · 47 total
- Other major peers for Aspirin
- Fluoxetine
- Ibandronate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.