Atenolol and Amiodarone Interaction
Drug interaction information between Atenolol and Amiodarone.
Atenolol and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atenolol and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines slow down your heart rate, so taking them at the same time can make your heart beat too slowly.
FDA Label Information
Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Epinephrine minor
- Indomethacin minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Atenolol + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Atenolol's 14. In the minor band specifically: Atenolol has 12 (also Clonidine, Epinephrine, Indomethacin, Dutasteride); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Atenolol and Amiodarone?
Both of these medicines slow down your heart rate, so taking them at the same time can make your heart beat too slowly.
Amiodarone carries more major-labeled pairs than Atenolol
SPL source-record counts only. This page's band is minor · classes on file: Atenolol (Beta-1 Selective Blocker); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Atenolol's 2. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 12 minor · 14 total
- Other minor peers for Atenolol
- Clonidine
- Epinephrine
- Indomethacin
- Dutasteride
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.