Atenolol and Indomethacin Interaction
Drug interaction information between Atenolol and Indomethacin.
Atenolol and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atenolol and Indomethacin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Indomethacin can prevent your blood pressure medicine from working as well as it should.
What To Do
Your doctor should check your blood pressure regularly to make sure it stays within a healthy range.
FDA Label Information
Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers.
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
Can I take Atenolol and Indomethacin together?
This is a minor interaction. Your doctor should check your blood pressure regularly to make sure it stays within a healthy range.
How serious is the interaction between Atenolol and Indomethacin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Atenolol and Indomethacin interact?
Indomethacin can prevent your blood pressure medicine from working as well as it should.
Understanding the Atenolol and Indomethacin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Atenolol belongs to the Beta-1 Selective Blocker class and Indomethacin belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Indomethacin can prevent your blood pressure medicine from working as well as it should. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Atenolol has 14 total documented interactions on file in this dataset, and Indomethacin has 35. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check your blood pressure regularly to make sure it stays within a healthy range. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Atenolol or Indomethacin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.