Atenolol and Indomethacin Interaction
Drug interaction information between Atenolol and Indomethacin.
Atenolol and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Atenolol and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Indomethacin can prevent your blood pressure medicine from working as well as it should.
FDA Label Information
Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers.
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Atenolol + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Atenolol's 14. In the minor band specifically: Atenolol has 12 (also Clonidine, Amiodarone, Epinephrine, Dutasteride); Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine).
What mechanism field is on file for Atenolol and Indomethacin?
Indomethacin can prevent your blood pressure medicine from working as well as it should.
Atenolol carries more major-labeled pairs than Indomethacin
SPL source-record counts only. This page's band is minor · classes on file: Atenolol (Beta-1 Selective Blocker); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Atenolol has 2 major-labeled pairs vs Indomethacin's 0. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 12 minor · 14 total
- Other minor peers for Atenolol
- Clonidine
- Amiodarone
- Epinephrine
- Dutasteride
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.