Rasagiline and Norepinephrine Interaction
Drug interaction information between Rasagiline and Norepinephrine.
Rasagiline and Norepinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rasagiline and Norepinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause a sudden release of a chemical called norepinephrine in your body. This can lead to a rise in your blood pressure.
FDA Label Information
Foods and medications containing large amounts of exogenous amines (e.g., from fermented cheese, herring, over-the-counter cough/cold medications) may cause release of norepinephrine resulting in a rise in systemic blood pressure.
Rasagiline Also Interacts With
- Meperidine moderate
- Dextromethorphan moderate
- Tranylcypromine moderate
- Ciprofloxacin minor
- Dopamine minor
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Rasagiline + Norepinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Rasagiline's 7. In the minor band specifically: Rasagiline has 4 (also Ciprofloxacin, Dopamine, Metoclopramide); Norepinephrine has 42 (also Amitriptyline, Linezolid, Nortriptyline, Desipramine).
What mechanism field is on file for Rasagiline and Norepinephrine?
This combination can cause a sudden release of a chemical called norepinephrine in your body. This can lead to a rise in your blood pressure.
Norepinephrine carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is minor · classes on file: Rasagiline (MAO-B Inhibitor); Norepinephrine (Vasopressor (Alpha-1 Agonist)).
Norepinephrine has 1 major-labeled pair vs Rasagiline's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Rasagiline
- Ciprofloxacin
- Dopamine
- Metoclopramide
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Nortriptyline
- Desipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.