Rasagiline and Ciprofloxacin Interaction
Drug interaction information between Rasagiline and Ciprofloxacin.
Rasagiline and Ciprofloxacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rasagiline and Ciprofloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin blocks the enzyme that breaks down rasagiline, which can double the amount of medicine in your body.
FDA Label Information
7.6 Ciprofloxacin or Other CYP1A2 Inhibitors Rasagiline plasma concentrations may increase up to 2 fold in patients using concomitant ciprofloxacin and other CYP1A2 inhibitors. Patients taking concomitant ciprofloxacin or other CYP1A2 inhibitors should not exceed a dose of rasagiline tablets 0.5 mg once daily [see Warnings and Precautions (5.4) and Clinical Pharmacology (12.3)] .
Rasagiline Also Interacts With
- Meperidine moderate
- Dextromethorphan moderate
- Tranylcypromine moderate
- Dopamine minor
- Norepinephrine minor
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Rasagiline + Ciprofloxacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ciprofloxacin has 14 labeled pairs on file vs Rasagiline's 7. In the minor band specifically: Rasagiline has 4 (also Dopamine, Norepinephrine, Metoclopramide); Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Carbamazepine, Clozapine).
What mechanism field is on file for Rasagiline and Ciprofloxacin?
Ciprofloxacin blocks the enzyme that breaks down rasagiline, which can double the amount of medicine in your body.
Ciprofloxacin carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is minor · classes on file: Rasagiline (MAO-B Inhibitor); Ciprofloxacin (Fluoroquinolone Antibiotic).
Ciprofloxacin has 1 major-labeled pair vs Rasagiline's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Rasagiline
- Dopamine
- Norepinephrine
- Metoclopramide
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Carbamazepine
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.