What the FDA labels say about taking them together
Dextromethorphan and rasagiline
Rasagiline's FDA label of June 30, 2020 names dextromethorphan in its contraindications section; dextromethorphan's label does not name rasagiline itself but warns about its class (MAO inhibitors). The rasagiline label: “Rasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.”
Check it at the source: the dextromethorphan FDA label on DailyMed (effective August 27, 2026); the rasagiline FDA label on DailyMed (effective June 30, 2020, Teva Pharmaceuticals USA, Inc.).
What does the dextromethorphan label say about rasagiline?
Dextromethorphan's label does not name rasagiline itself; it warns about its class (MAO inhibitors):
Dextromethorphan label, warningsWarnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
Dextromethorphan label, warningsIf you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Source: FDA drug label (Good Sense Cough DM), L. Perrigo Company, effective August 27, 2026 (SPL set 5a2e9bef-42cb-4b72-9a26-c3ae71dcb4ea), via openFDA; the full label on DailyMed
What does the rasagiline label say about dextromethorphan?
Rasagiline label, contraindicationsRasagiline is contraindicated for use with dextromethorphan because of risk of episode of psychosis or bizarre behavior.
Rasagiline label, drug interactionsDRUG INTERACTIONS Meperidine: Risk of serotonin syndrome ( 4 , 7.1 ) Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 ) MAO inhibitors:
Source: FDA drug label (Rasagiline), Teva Pharmaceuticals USA, Inc., effective June 30, 2020 (SPL set e802c83c-e581-4a11-b83d-1df47120078d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextromethorphan | Rasagiline | |
|---|---|---|
| Labeled for | Cough and cold | Parkinson's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.122 per unit 15 mg softgel | $0.521 per tablet 0.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once