Rasagiline and Metoclopramide Interaction
Drug interaction information between Rasagiline and Metoclopramide.
Rasagiline and Metoclopramide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rasagiline and Metoclopramide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Metoclopramide blocks the effects of dopamine, which is the opposite of how rasagiline works. This can make rasagiline less effective at treating your condition.
FDA Label Information
7.8 Dopaminergic Antagonists It is possible that dopamine antagonists, such as antipsychotics or metoclopramide, could diminish the effectiveness of rasagiline.
Rasagiline Also Interacts With
- Meperidine moderate
- Dextromethorphan moderate
- Tranylcypromine moderate
- Ciprofloxacin minor
- Dopamine minor
Metoclopramide Also Interacts With
- Posaconazole major
- Lidocaine Topical moderate
- Rivastigmine moderate
- Tacrolimus Topical moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Rasagiline + Metoclopramide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoclopramide has 23 labeled pairs on file vs Rasagiline's 7. In the minor band specifically: Rasagiline has 4 (also Ciprofloxacin, Dopamine, Norepinephrine); Metoclopramide has 18 (also Acetaminophen, Cyclosporine, Tetracycline, Atovaquone/Proguanil).
What mechanism field is on file for Rasagiline and Metoclopramide?
Metoclopramide blocks the effects of dopamine, which is the opposite of how rasagiline works. This can make rasagiline less effective at treating your condition.
Metoclopramide carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is minor · classes on file: Rasagiline (MAO-B Inhibitor); Metoclopramide (Prokinetic / Antiemetic).
Metoclopramide has 1 major-labeled pair vs Rasagiline's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other minor peers for Rasagiline
- Ciprofloxacin
- Dopamine
- Norepinephrine
1 major · 4 moderate · 18 minor · 23 total
- Other minor peers for Metoclopramide
- Acetaminophen
- Cyclosporine
- Tetracycline
- Atovaquone/Proguanil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.