What the FDA labels say about taking them together
Meperidine and rasagiline
Rasagiline's FDA label of June 30, 2020 names meperidine in its contraindications section; meperidine's label does not name rasagiline itself but warns about its class (MAO inhibitors). The rasagiline label: “DRUG INTERACTIONS Meperidine: Risk of serotonin syndrome Dextromethorphan: Risk of psychosis or bizarre behavior MAO inhibitors:”
Check it at the source: the meperidine FDA label on DailyMed (effective November 29, 2025, EPIC PHARMA, LLC); the rasagiline FDA label on DailyMed (effective June 30, 2020, Teva Pharmaceuticals USA, Inc.).
What does the meperidine label say about rasagiline?
Meperidine's label does not name rasagiline itself; it warns about its class (MAO inhibitors):
Meperidine label, boxed warningConcomitant use of Meperidine Hydrochloride Tablets with Monoamine Oxidase Inhibitors (MAOIs) Concomitant use of meperidine hydrochloride tablets with monoamine oxidase inhibitors (MAOIs) can result in coma, severe respiratory depression, cyanosis, and hypotension.
Meperidine label, boxed warningUse of meperidine hydrochloride tablets with MAOIs within last 14 days is contraindicated [see Contraindications (4), Warnings and Precautions (5.8), Drug Interactions (7) ].
Source: FDA drug label (Meperidine Hydrochloride), EPIC PHARMA, LLC, effective November 29, 2025 (SPL set fae5cc34-5917-4445-9516-25f97ffca8db), via openFDA; the full label on DailyMed
What does the rasagiline label say about meperidine?
Rasagiline label, contraindicationsCONTRAINDICATIONS Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene, and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome [see Warnings and Precautions ( 5.2 )].
Rasagiline label, drug interactionsDRUG INTERACTIONS Meperidine: Risk of serotonin syndrome ( 4 , 7.1 ) Dextromethorphan: Risk of psychosis or bizarre behavior ( 4 , 7.2 ) MAO inhibitors:
Rasagiline label, warnings and precautionsSerotonin syndrome has also been reported with concomitant use of rasagiline with meperidine, tramadol, methadone, or propoxyphene.
Source: FDA drug label (Rasagiline), Teva Pharmaceuticals USA, Inc., effective June 30, 2020 (SPL set e802c83c-e581-4a11-b83d-1df47120078d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Meperidine | Rasagiline | |
|---|---|---|
| Labeled for | Pain | Parkinson's disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.157 per mL 50 mg/5 mL solution | $0.521 per tablet 0.5 mg tablet |
| Shortage now | Listed; available | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once