Rasagiline and Tranylcypromine Interaction
Drug interaction information between Rasagiline and Tranylcypromine.
Rasagiline and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rasagiline and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the levels of certain chemicals in the brain and body. Taking them together can lead to dangerously high blood pressure or a serious condition called serotonin syndrome.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Rasagiline Also Interacts With
- Meperidine moderate
- Dextromethorphan moderate
- Ciprofloxacin minor
- Dopamine minor
- Norepinephrine minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Rasagiline + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Rasagiline's 7. In the moderate band specifically: Rasagiline has 3 (also Meperidine, Dextromethorphan); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Rasagiline and Tranylcypromine?
Both drugs increase the levels of certain chemicals in the brain and body. Taking them together can lead to dangerously high blood pressure or a serious condition called serotonin syndrome.
Tranylcypromine carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is moderate · classes on file: Rasagiline (MAO-B Inhibitor); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Rasagiline's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 4 minor · 7 total
- Other moderate peers for Rasagiline
- Meperidine
- Dextromethorphan
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.