Pravastatin and Diltiazem Interaction
Drug interaction information between Pravastatin and Diltiazem.
Pravastatin and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pravastatin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly affect how the body absorbs or processes each other.
FDA Label Information
In the same study, there was no significant change in 20 mg single dose pravastatin AUC and C max during diltiazem coadministration. Diltiazem plasma levels were not significantly affected by lovastatin or pravastatin.
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Pravastatin's 16. In the minor band specifically: Pravastatin has 7 (also Azithromycin, Darunavir, Efavirenz, Glecaprevir/Pibrentasvir); Diltiazem has 35 (also Buspirone, Lovastatin, Cyclosporine, Carbamazepine).
What mechanism field is on file for Pravastatin and Diltiazem?
These two drugs do not significantly affect how the body absorbs or processes each other.
Diltiazem carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is minor · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Pravastatin's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other minor peers for Pravastatin
- Azithromycin
- Darunavir
- Efavirenz
- Glecaprevir/Pibrentasvir
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Lovastatin
- Cyclosporine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.