Pravastatin and Colchicine Interaction
Drug interaction information between Pravastatin and Colchicine.
Pravastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pravastatin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together increases the risk of developing severe muscle pain or a dangerous type of muscle breakdown.
FDA Label Information
7.3 Colchicine The risk of myopathy/rhabdomyolysis is increased with concomitant administration of colchicine [see Warnings and Precautions (5.1) ]. 7.3 Colchicine The risk of myopathy/rhabdomyolysis is increased with concomitant administration of colchicine [see Warnings and Precautions (5.1) ].
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Gemfibrozil moderate
- Niacin moderate
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Pravastatin's 16. In the moderate band specifically: Pravastatin has 9 (also Cyclosporine, Erythromycin, Clarithromycin, Gemfibrozil); Colchicine has 9 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fenofibrate).
What mechanism field is on file for Pravastatin and Colchicine?
Taking these two drugs together increases the risk of developing severe muscle pain or a dangerous type of muscle breakdown.
Colchicine carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Pravastatin's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Erythromycin
- Clarithromycin
- Gemfibrozil
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fenofibrate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.