Pravastatin and Azithromycin Interaction
Drug interaction information between Pravastatin and Azithromycin.
Pravastatin and Azithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pravastatin and Azithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can increase the amount of the cholesterol medicine that stays in your blood.
FDA Label Information
Other macrolides (e.g., erythromycin and azithromycin) have the potential to increase statin exposures while used in combination. Other macrolides (e.g., erythromycin and azithromycin) have the potential to increase statin exposures while used in combination.
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Azithromycin Also Interacts With
- Theophylline major
- Warfarin minor
- Digoxin minor
- Colchicine minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Azithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pravastatin has 16 labeled pairs on file vs Azithromycin's 9. In the minor band specifically: Pravastatin has 7 (also Darunavir, Diltiazem, Efavirenz, Glecaprevir/Pibrentasvir); Azithromycin has 8 (also Warfarin, Digoxin, Colchicine, Phenytoin).
What mechanism field is on file for Pravastatin and Azithromycin?
This antibiotic can increase the amount of the cholesterol medicine that stays in your blood.
Azithromycin carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is minor · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Azithromycin (Macrolide Antibiotic).
Azithromycin has 1 major-labeled pair vs Pravastatin's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other minor peers for Pravastatin
- Darunavir
- Diltiazem
- Efavirenz
- Glecaprevir/Pibrentasvir
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Azithromycin
- Warfarin
- Digoxin
- Colchicine
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.