Pravastatin and Efavirenz Interaction
Drug interaction information between Pravastatin and Efavirenz.
Pravastatin and Efavirenz have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pravastatin and Efavirenz. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Efavirenz can lower the amount of this cholesterol medicine in your blood, which might make it work less effectively.
FDA Label Information
HMG-CoA reductase inhibitors: Atorvastatin Pravastatin Simvastatin ↓ atorvastatin * ↓ pravastatin * ↓ simvastatin * Plasma concentrations of atorvastatin, pravastatin, and simvastatin decreased.
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Efavirenz Also Interacts With
- Clarithromycin moderate
- Sofosbuvir/Velpatasvir moderate
- Posaconazole moderate
- Atorvastatin minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Efavirenz/Emtricitabine/Tenofovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Efavirenz has 32 labeled pairs on file vs Pravastatin's 16. In the minor band specifically: Pravastatin has 7 (also Azithromycin, Darunavir, Diltiazem, Glecaprevir/Pibrentasvir); Efavirenz has 29 (also Atorvastatin, Sertraline, Bupropion, Simvastatin).
What mechanism field is on file for Pravastatin and Efavirenz/Emtricitabine/Tenofovir?
Efavirenz can lower the amount of this cholesterol medicine in your blood, which might make it work less effectively.
Efavirenz's labeled portfolio outnumbers Pravastatin
SPL source-record counts only. This page's band is minor · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Efavirenz (NNRTI / NRTI Combination).
0 major · 9 moderate · 7 minor · 16 total
- Other minor peers for Pravastatin
- Azithromycin
- Darunavir
- Diltiazem
- Glecaprevir/Pibrentasvir
0 major · 3 moderate · 29 minor · 32 total
- Other minor peers for Efavirenz
- Atorvastatin
- Sertraline
- Bupropion
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.