Pravastatin and Cyclosporine Interaction
Drug interaction information between Pravastatin and Cyclosporine.
Pravastatin and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pravastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine causes more of the statin to stay in your blood, which can lead to muscle damage.
FDA Label Information
7 DRUG INTERACTIONS For the concurrent therapy of either cyclosporine, fibrates, niacin (nicotinic acid), or erythromycin, the risk of myopathy increases [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ]. (7) Cyclosporine: combination increases exposure. (2.7, 7.2) 7.1 Cyclosporine The risk of myopathy/rhabdomyolysis is increased with concomitant administration of cyclosporine.
Pravastatin Also Interacts With
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
- Niacin moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Pravastatin's 16. In the moderate band specifically: Pravastatin has 9 (also Erythromycin, Clarithromycin, Colchicine, Gemfibrozil); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Pravastatin and Cyclosporine?
Cyclosporine causes more of the statin to stay in your blood, which can lead to muscle damage.
Cyclosporine carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Pravastatin's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Erythromycin
- Clarithromycin
- Colchicine
- Gemfibrozil
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.