Pravastatin and Erythromycin Interaction
Drug interaction information between Pravastatin and Erythromycin.
Pravastatin and Erythromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pravastatin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can increase the amount of statin in your system, making muscle side effects more likely.
FDA Label Information
7 DRUG INTERACTIONS For the concurrent therapy of either cyclosporine, fibrates, niacin (nicotinic acid), or erythromycin, the risk of myopathy increases [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3) ]. Other macrolides (e.g., erythromycin and azithromycin) have the potential to increase statin exposures while used in combination. Other macrolides (e.g., erythromycin and azithromycin) have the potential to increase statin exposures while used in combination.
Pravastatin Also Interacts With
- Cyclosporine moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
- Niacin moderate
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Erythromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Pravastatin's 16. In the moderate band specifically: Pravastatin has 9 (also Cyclosporine, Clarithromycin, Colchicine, Gemfibrozil); Erythromycin has 6 (also Lefamulin, Lovastatin, Midazolam, Rivaroxaban).
What mechanism field is on file for Pravastatin and Erythromycin?
This antibiotic can increase the amount of statin in your system, making muscle side effects more likely.
Erythromycin carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Pravastatin's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Clarithromycin
- Colchicine
- Gemfibrozil
4 major · 6 moderate · 53 minor · 63 total
- Other moderate peers for Erythromycin
- Lefamulin
- Lovastatin
- Midazolam
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.