Pravastatin and Gemfibrozil Interaction
Drug interaction information between Pravastatin and Gemfibrozil.
Pravastatin and Gemfibrozil have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pravastatin and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these medications at the same time significantly raises the risk of serious muscle injury and breakdown.
FDA Label Information
7.4 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of Pravastatin Sodium with gemfibrozil should be avoided [see Warnings and Precautions (5.1) ]. 7.4 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of Pravastatin Sodium with gemfibrozil should be avoided [see Warnings and Precautions (5.1) ].
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Niacin moderate
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Gemfibrozil?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Pravastatin's 16. In the moderate band specifically: Pravastatin has 9 (also Cyclosporine, Erythromycin, Clarithromycin, Colchicine); Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Fluvastatin, Lovastatin).
What mechanism field is on file for Pravastatin and Gemfibrozil?
Using these medications at the same time significantly raises the risk of serious muscle injury and breakdown.
Gemfibrozil carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is moderate · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Pravastatin's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Erythromycin
- Clarithromycin
- Colchicine
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Fluvastatin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.