Pravastatin and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Pravastatin and Glecaprevir/Pibrentasvir.
Pravastatin and Glecaprevir/Pibrentasvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pravastatin and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can increase the amount of pravastatin in your bloodstream.
FDA Label Information
Pravastatin ↑ pravastatin Coadministration may increase the concentration of pravastatin. Reduce pravastatin dose by 50% when coadministered with MAVYRET.
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Pravastatin + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Pravastatin's 16. In the minor band specifically: Pravastatin has 7 (also Azithromycin, Darunavir, Diltiazem, Efavirenz); Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Amlodipine, Losartan, Omeprazole).
What mechanism field is on file for Pravastatin and Glecaprevir/Pibrentasvir?
Taking these drugs together can increase the amount of pravastatin in your bloodstream.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Pravastatin
SPL source-record counts only. This page's band is minor · classes on file: Pravastatin (HMG-CoA Reductase Inhibitor (Statin)); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Pravastatin's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 7 minor · 16 total
- Other minor peers for Pravastatin
- Azithromycin
- Darunavir
- Diltiazem
- Efavirenz
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Amlodipine
- Losartan
- Omeprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.