Nifedipine and Theophylline Interaction
Drug interaction information between Nifedipine and Theophylline.
Nifedipine and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Nifedipine and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nifedipine can change how your body processes theophylline, which may lead to an increase in the amount of theophylline in your bloodstream.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Nifedipine Also Interacts With
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
- Fluconazole minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Nifedipine's 26. In the major band specifically: Nifedipine has 1; Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Nifedipine and Theophylline?
Nifedipine can change how your body processes theophylline, which may lead to an increase in the amount of theophylline in your bloodstream.
Theophylline carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is major · classes on file: Nifedipine (Calcium Channel Blocker); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Nifedipine's 1.
1 major · 3 moderate · 22 minor · 26 total
Nifedipine has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.