Nifedipine and Fluconazole Interaction
Drug interaction information between Nifedipine and Fluconazole.
Nifedipine and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nifedipine and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that breaks down nifedipine, causing the drug to build up in your system.
FDA Label Information
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Nifedipine has 22 (also Fluoxetine, Erythromycin, Clarithromycin, Itraconazole); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Nifedipine and Fluconazole?
Fluconazole blocks the enzyme that breaks down nifedipine, causing the drug to build up in your system.
Fluconazole carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Nifedipine (Calcium Channel Blocker); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Erythromycin
- Clarithromycin
- Itraconazole
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.