Nifedipine and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Nifedipine and Nirmatrelvir/Ritonavir.
Nifedipine and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nifedipine and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine blocks the enzyme that usually breaks down nifedipine, which causes the drug to build up in your body. This can lead to much stronger effects and more side effects than usual.
FDA Label Information
Calcium channel blockers amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blocker Caution is warranted and clinical monitoring of patients is recommended.
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
- Fluconazole minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Nifedipine's 26. In the moderate band specifically: Nifedipine has 3 (also Phenytoin, Tacrolimus Topical); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Nifedipine and Nirmatrelvir/Ritonavir?
This medicine blocks the enzyme that usually breaks down nifedipine, which causes the drug to build up in your body. This can lead to much stronger effects and more side effects than usual.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is moderate · classes on file: Nifedipine (Calcium Channel Blocker); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Nifedipine's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other moderate peers for Nifedipine
- Phenytoin
- Tacrolimus Topical
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.