Nifedipine and Clarithromycin Interaction
Drug interaction information between Nifedipine and Clarithromycin.
Nifedipine and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nifedipine and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzyme that clears nifedipine from your system, causing the blood pressure medicine to build up.
FDA Label Information
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Nifedipine has 22 (also Fluoxetine, Fluconazole, Erythromycin, Itraconazole); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Nifedipine and Clarithromycin?
Clarithromycin blocks the enzyme that clears nifedipine from your system, causing the blood pressure medicine to build up.
Clarithromycin carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Nifedipine (Calcium Channel Blocker); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Fluconazole
- Erythromycin
- Itraconazole
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.