What the FDA labels say about taking them together
Clarithromycin and nifedipine
Clarithromycin's FDA label of April 9, 2026 names nifedipine in its drug interactions section, and nifedipine's label names clarithromycin too. The clarithromycin label: “Hypotension and peripheral edema were observed when clarithromycin was taken concomitantly with nifedipine.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the clarithromycin label say about nifedipine?
Clarithromycin label, drug interactionsHypotension and peripheral edema were observed when clarithromycin was taken concomitantly with nifedipine [see Warnings and Precautions (5.4) ].
Clarithromycin label, warnings and precautionsThese include colchicine toxicity with colchicine; markedly increased transaminases with lomitapide; rhabdomyolysis with simvastatin, lovastatin, and atorvastatin; hypoglycemia and cardiac arrhythmias (e.g., torsades de pointes ) with disopyramide; and hypotension and acute kidney injury with calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, amlodipine, diltiazem, nifedipine).
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the nifedipine label say about clarithromycin?
Nifedipine label, drug interactionsCYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.
Procardia Xl label (Pfizer Laboratories Div Pfizer Inc, December 16, 2025), drug interactionsCYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Source: FDA drug label (Procardia Xl, NDA019684), Pfizer Laboratories Div Pfizer Inc, effective December 16, 2025 (SPL set 8ebcb33c-f43b-4b36-9f94-9774b2a59e06), via openFDA
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Nifedipine | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | High blood pressure, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.130 per tablet 30 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once