Nifedipine and Erythromycin Interaction
Drug interaction information between Nifedipine and Erythromycin.
Nifedipine and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nifedipine and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down how your body breaks down nifedipine, which can lead to higher levels of the drug in your blood.
FDA Label Information
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluoxetine minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Nifedipine has 22 (also Fluoxetine, Fluconazole, Clarithromycin, Itraconazole); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Nifedipine and Erythromycin?
Erythromycin slows down how your body breaks down nifedipine, which can lead to higher levels of the drug in your blood.
Erythromycin carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Nifedipine (Calcium Channel Blocker); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluoxetine
- Fluconazole
- Clarithromycin
- Itraconazole
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.