Nifedipine and Fluoxetine Interaction
Drug interaction information between Nifedipine and Fluoxetine.
Nifedipine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nifedipine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine slows down the process that removes nifedipine from your body, which can lead to higher drug levels.
FDA Label Information
CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Nifedipine Also Interacts With
- Theophylline major
- Phenytoin moderate
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Fluconazole minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Nifedipine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Nifedipine's 26. In the minor band specifically: Nifedipine has 22 (also Fluconazole, Erythromycin, Clarithromycin, Itraconazole); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Nifedipine and Fluoxetine?
Fluoxetine slows down the process that removes nifedipine from your body, which can lead to higher drug levels.
Fluoxetine carries more major-labeled pairs than Nifedipine
SPL source-record counts only. This page's band is minor · classes on file: Nifedipine (Calcium Channel Blocker); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Nifedipine's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Nifedipine
- Fluconazole
- Erythromycin
- Clarithromycin
- Itraconazole
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.