What the FDA labels say about taking them together
Fluoxetine and nifedipine
Nifedipine's FDA label of December 24, 2024 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name nifedipine. The nifedipine label: “CYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the fluoxetine label say about nifedipine?
Fluoxetine's label (effective January 8, 2026) does not name nifedipine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the nifedipine label say about fluoxetine?
Nifedipine label, drug interactionsCYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.
Procardia Xl label (Pfizer Laboratories Div Pfizer Inc, December 16, 2025), drug interactionsCYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Source: FDA drug label (Procardia Xl, NDA019684), Pfizer Laboratories Div Pfizer Inc, effective December 16, 2025 (SPL set 8ebcb33c-f43b-4b36-9f94-9774b2a59e06), via openFDA
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Nifedipine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | High blood pressure, Angina |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $0.130 per tablet 30 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once